Abstract:

TSG-6 protein is a protective inflammatory factor, which plays the role of anti-inflammatory by binding to hyaluronic acid, chondroitin sulfate, or proteoglycan to mediate inflammatory cell migration and adhesion, and then participate the immune regulation and extracellular matrix remodeling. Recombinant TSG-6 protein has been applied to a variety of disease models, and has shown a broad and strong inhibition of inflammation. Recent studies have found that TSG-6 not only can directly ameliorate the pathologic manifestation of various ophthalmic diseases, but also can act as the media of the stem cells to inhibit inflammatory responses. This suggests that TSG-6 may be a therapeutic target for ophthalmic diseases, with a potential clinical value for clinical application.